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Friday, July 17, 2020 | History

3 edition of The Interferons found in the catalog.

The Interferons

The Interferons

characterization and application

  • 171 Want to read
  • 18 Currently reading

Published by Wiley-VCH in Weinheim .
Written in English

    Subjects:
  • Interferon

  • Edition Notes

    Includes bibliographical references and index

    Statementedited by Anthony Meager
    ContributionsMeager, Anthony
    The Physical Object
    Paginationl, 410 p. :
    Number of Pages410
    ID Numbers
    Open LibraryOL17210268M
    ISBN 103527311807
    ISBN 109783527311804

      Type I interferons as boosters of immune responses: implication in SLE pathogenesis. Type I interferons are constitutively expressed at low levels; expression is rapidly enhanced upon viral or bacterial infection, aiming for an effective immune response against the pathogens [3,35].Type I interferons induce an antiviral state in cells by suppressing . Interferons are signaling proteins in immune systems that have long been appreciated for their role in defending the body against viral attacks. Interferons hinder viruses from multiplying inside host cells, activate killer cells and macrophages (engulfing cells), and communicate with lymphocytes to help host cells deal with viral infection. Now researchers at the University of .

    This book is an update of Interferon, published in by Dr. Jan Vilcek.   Early clinical studies. The discovery of interferons was a result of research by Isaacs & Lindenmann in the field of viral interference [], the ability of an active or inactivated virus to interfere with the growth of an unrelated , viral interference had been considered to be due directly to the action of one virus on the pathologic activity of a second .

    IFN-c is produced by Th1 CD4+ helper T cells and by nearly all CD8+ cells, as a result of transcriptional activation induced by exposure to antigen-presenting cells (reviewed in Young, ). In naive and memory CD4+ T cells, the IFN-c promoter is . The book opens with a chapter that comprehensively reviews the antiviral effects of extracellular double-stranded RNA, the viral toxin. This is followed by chapters that review the properties of type I and type III interferons, and the role of interferon-stimulated genes. The next five chapters are devoted to understanding the diverse strategies used by clinically relevant human viruses .


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The Interferons Download PDF EPUB FB2

About this book At long last, the first book to cover all important areas of interferon science in one volume. Top scientists, including many pioneers in the field, highlight the role of interferons as research tools and as therapeutic agents in clinical applications.

Interferons are proteins that are part of your natural defenses. They tell your immune system that germs or cancer cells are in your body.

And they trigger killer immune cells to fight those invaders. Interferons also activate other cells that serve as part of the immune system and destroy invading pathogens. Interferons are classed as: alpha (from white cells), beta (from fibroblasts) and gamma (from lymphocytes).

Interferons enhance the immune system in many ways so can be used to treat different conditions involving the immune system. Book chapter Full text access EXPRESSION OF THE CLONED GENES FOR HUMAN INTERFERON β1 IN E.

COLI AND IN CULTURED MOUSE CELLS T. Taniguchi, The Interferons book. Ohno and C. Takaoka Pages 15 - Summary: Top scientists, including many pioneers in the field, highlight the role of interferons as research tools and as therapeutic agents in clinical applications.

Types of interferon. Based on the type of receptor through which they signal, human interferons have been classified into three major types. Interferon type I: All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α/β receptor that consists of IFNAR1 and IFNAR2 chains.

The type I interferons present in humans are IFN-α, IFN-β, IFN-ε, IFN-κ and IFN. Troy L. Ott, Alan D. Ealy, in Encyclopedia of Reproduction (Second Edition), Summary. Interferons are a large family of related cytokines first The Interferons book by their ability to confer resistance to viral infections.

They are firmly established as components of the innate arm of the immune system providing rapid and broad protection against a wide variety of invading. IFN-alpha alone was compared with observation in 12 of the 14 trials, and 17 comparisons (IFN-alpha vs comparator) were generated in total.

IFN-alpha treatment was. Interferon, any of several related proteins that are produced by the body’s cells as a defensive response to viruses. They are important modulators of the immune response. Interferon was named for its ability to interfere with viral proliferation.

The various forms of interferon. Interferons also regulate the growth, differentiation and functions of different types of immune cells in animals.

Several classes of interferons are recognized in eukaryotes such as INFα, INFβ and INFγ. INFα and INFβ are produced by virus infected fibroblasts. The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses.

Now expanded to two volumes, co-edited by Michael T Lotze, and written by over international experts, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The Story of Interferon, written by one of the principals in the clinical evolution of interferons, is a reassuring example that perseverance can bring an important scientific observation to clinical by:   'This book is compelling reading for those interested in the interferon story, including the historical background and the scientists behind the discovery.

The book is a thorough and readable account that is unique for interferon and has parallels with other major discoveries.' - Samuel Baron, M.D., University of Texas Medical BranchCited by: Interferon-based antitumour therapy has been introduced quite recently. Towards the mid-Eighties, interferons started to be massively used against a large number of tumours.

Actually, in this case, the expectations related to the use of interferons have been met but partially. As a matter of fact, a survey was recently published by Jonasch.

The availability of genetically modified mice that are lacking either essential components of the interferon inducing pathway, or interferon signaling pathway fully confirmed the original idea, made soon after its discovery, that interferon is the first cellular defense against viral infection.

Interferon type I: All type I IFNs bind to a specific cell surface receptor complex, known as the IFN-α receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains.

The type I interferons present in humans are IFN-α, IFN-β and IFN-ω. Interferon type II: These bind to IFNGR that consist of IFNGR1 and IFNGR2 chains. In humans this is IFN-γ. About this book. Introduction. Interferon has been and continues to be one of the more fas­ cinating substances produced by apparently all animals in response to particular stimuli.

It has led to major revisions in concepts of cellular immunity and theories on the recovery of multicellular systems from viral infection. Since its discovery. Interferon treatment for hepatitis C would typically last 24–48 weeks (6–12 months). Interferons caused many long-term side effects.

Description Interferons documents the proceedings of a major international conference on Chemistry and Biology of Interferons: Relationship to Therapeutics held at Book Edition: 1. Free Online Library: The Interferons: Characterization and Application.(Brief Article, Book Review) by "SciTech Book News"; Publishing industry Library and information science Science and technology, general Books Book reviews.

Printer Friendly. 33, articles and books. Overview of Interferon: Characteristics, signaling and anticancer effect Published: Ap amino acids with a molecular weight of 20 kD and are easily degraded by proteases, diethyl either, chloroform and ketones.

Interferon-a (a family of about 20 related proteins) and interferon-b are particularly potent as antiviral agents.

They are not expressed in normal cells, but viral infection of a cell causes interferons to be made and released from the cell (that cell will often eventually die as a result of the infection). Interferons got their name because they "interfere" with viruses and keep them from multiplying.

Inthe first lab-made interferon was created to treat certain types of cancer. It was one of.